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Human Cytomegalovirus US28 Facilitates Cell-to-Cell Viral Dissemination

12 Mar 2014

Abstract excerpt

Human cytomegalovirus (HCMV) encodes a number of viral proteins with homology to cellular G protein-coupled receptors (GPCRs). These viral GPCRs, including US27, US28, UL33, and UL78, have been ascribed numerous functions during infection, including activating diverse cellular pathways, binding to immunomodulatory chemokines, and impacting virus dissemination. To investigate the role of US28 during virus...

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PMID: 24625810
DOI: 10.3390/v6031202

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