The human cytomegalovirus-encoded G protein–coupled receptor UL33 exhibits oncomodulatory properties

Abstract excerpt

Herpesviruses can rewire cellular signaling in host cells by expressing viral G protein–coupled receptors (GPCRs). These viral receptors exhibit homology to human chemokine receptors, but some display constitutive activity and promiscuous G protein coupling. Human cytomegalovirus (HCMV) has been detected in multiple cancers, including glioblastoma, and its genome encodes four GPCRs. One of these receptors, US28,...

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