Article

The human cytomegalovirus G-protein coupled receptor US28 promotes latency by attenuating c-fos

2018-10-03

Abstract excerpt

Human cytomegalovirus (HCMV) is a ubiquitous pathogen that undergoes latency in cells of the hematopoietic compartment, though the mechanisms underlying establishment and maintenance of latency remain elusive. We previously reported that the HCMV-encoded G-protein coupled receptor (GPCR) homolog, US28 is required for successful latent infection. We now show that US28 protein (pUS28) provided in trans complements...

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Literature Corpus work: a723f311-fefa-5151-b388-2d2f09707aa2
DOI: 10.1101/434605

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