Article

Structural basis for synergistic antibody protection against the essential malaria invasion complex protein RIPR

2025-12-18

Abstract excerpt

<h4>SUMMARY</h4> Plasmodium falciparum RH5-interacting protein (RIPR) is central to the essential PTRAMP-CSS-RIPR-CyRPA-RH5 (PCRCR)-complex; a leading target of blood-stage malaria vaccines. However, mechanisms whereby anti-RIPR antibodies inhibit parasite invasion are poorly understood. Here, we characterise 83 human IgG mAbs from RIPR-vaccinated Kymouse platform mice. Single mAbs have minimal neutralising activ...

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Identifiers and source

Literature Corpus work: 5908228c-c293-592b-95d1-8113c589f728
DOI: 10.64898/2025.12.16.693247

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