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The RH5-CyRPA-Ripr Complex as a Malaria Vaccine Target

28 Apr 2020

Abstract excerpt

Despite ongoing efforts, a highly effective vaccine against Plasmodium falciparum remains elusive. Vaccines targeting the pre-erythrocytic stages of the P. falciparum life cycle are the most advanced to date, affording moderate levels of efficacy in field trials. However, the discovery that the members of the merozoite PfRH5-PfCyRPA-PfRipr (RCR) complex are capable of inducing strain-transcendent neutralizing...

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PMID: 32359873
DOI: 10.1016/j.pt.2020.04.003

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