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PCRCR complex is essential for invasion of human erythrocytes by Plasmodium falciparum

17 Nov 2022

Abstract excerpt

The most severe form of malaria is caused by Plasmodium falciparum. These parasites invade human erythrocytes, and an essential step in this process involves the ligand PfRh5, which forms a complex with cysteine-rich protective antigen (CyRPA) and PfRh5-interacting protein (PfRipr) (RCR complex) and binds basigin on the host cell. We identified a heteromeric disulfide-linked complex consisting of P. falciparum...

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PMID: 36396942
DOI: 10.1038/s41564-022-01261-2

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