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Divergent roles for the RH5 complex components, CyRPA and RIPR in human-infective malaria parasites

11 Jun 2019

Abstract excerpt

Malaria is caused by Plasmodium parasites, which invade and replicate in erythrocytes. For Plasmodium falciparum, the major cause of severe malaria in humans, a heterotrimeric complex comprised of the secreted parasite proteins, PfCyRPA, PfRIPR and PfRH5 is essential for erythrocyte invasion, mediated by the interaction between PfRH5 and erythrocyte receptor basigin (BSG). However, whilst CyRPA and RIPR are...

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PMID: 31185066
DOI: 10.1371/journal.ppat.1007809

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