Article

Ultra-sensitive molecular residual disease detection through whole genome sequencing with single-read error correction

2024-01-13

Abstract excerpt

While whole genome sequencing (WGS) of cell-free DNA (cfDNA) holds enormous promise for molecular residual disease (MRD) detection, its performance is limited by WGS error rate. Here we introduce AccuScan, an efficient cfDNA WGS technology that enables genome-wide error correction at single read level, achieving an error rate of 4.2×10 -7 , which is about two orders of magnitude lower than a read-centric de-noisin...

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Literature Corpus work: 58f67fb3-0742-51cf-ac33-17302ea009a9
DOI: 10.1101/2024.01.13.24301070

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