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MAESTRO-Pool Enables Highly Parallel and Specific Mutation-Enrichment Sequencing for Minimal Residual Disease Detection in Cohort Studies.

Clinical chemistry - 7 Feb 2024

Blewett Timothy, Rhoades Justin, Liu Ruolin, Xiong Kan, Sridhar Sainetra, Crnjac Andjela, Cheng Ju, Lawless Aleigha R, Frederick Dennie T, Flaherty Keith T, Makrigiorgos Gerassimos Mike, Adalsteinsson Viktor A

Abstract excerpt

BACKGROUND: Tracing patient-specific tumor mutations in cell-free DNA (cfDNA) for minimal residual disease (MRD) detection is promising but challenging. Assaying more mutations and cfDNA stands to improve MRD detection but requires highly accurate, efficient sequencing methods and proper calibration to prevent false detection with bespoke tests. METHODS: MAESTRO (Minor Allele Enriched Sequencing Through...

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Identifiers

PMID: 38069911
DOI: 10.1093/clinchem/hvad203
PMCID: PMC10847667

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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