Article

<i>cfTrack</i>: Exome-wide mutation analysis of cell-free DNA to simultaneously monitor the full spectrum of cancer treatment outcomes: MRD, recurrence, and evolution

2021-11-11

Abstract excerpt

<h4>Purpose</h4> Cell-free DNA (cfDNA) offers a non-invasive approach to monitor cancer. Here we develop a method using whole-exome sequencing (WES) of cfDNA for simultaneously monitoring the full spectrum of cancer treatment outcomes, including MRD, recurrence, evolution, and second primary cancer. <h4>Experimental Design</h4> Three simulation datasets were generated from 26 cancer patients to benchmark the detec...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 73463c3f-0443-5f12-9b69-5d1c984615ba
DOI: 10.1101/2021.11.07.21265999

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

<i>cfTrack</i>: Exome-wide mutation analysis of cell-free DNA to simultaneously monitor the full spectrum of cancer treatment outcomes: MRD, recurrence, and evolutionDOI 10.1101/2021.11.07.21265999Read

cfTrack: A Method of Exome-Wide Mutation Analysis of Cell-free DNA to Simultaneously Monitor the Full Spectrum of Cancer Treatment Outcomes Including MRD, Recurrence, and Evolution.Semantic proximity Read

Ultra-sensitive molecular residual disease detection through whole genome sequencing with single-read error correctionSemantic proximity Read

Ultra-low coverage fragmentomic model of cell-free DNA for cancer detection based on whole-exome regionsSemantic proximity Read

Genome-wide cell-free DNA mutational integration enables ultra-sensitive cancer monitoring.Semantic proximity Read

Plasma cell-free DNA as a sensitive biomarker for multi-cancer detection and immunotherapy outcomes predictionSemantic proximity Read

Leveraging sequences missing from the human genome to diagnose cancerSemantic proximity Read

Multi-modal cell-free DNA genomic and fragmentomic patterns enhance cancer survival and recurrence analysisSemantic proximity Read

Scalable whole-exome sequencing of cell-free DNA reveals high concordance with metastatic tumorsSemantic proximity Read

Integrative modeling of tumor genomes and epigenomes for enhanced cancer diagnosis by cell-free DNA.Semantic proximity Read

Machine learning guided signal enrichment for ultrasensitive plasma tumor burden monitoringSemantic proximity Read

Phenotypes from cell-free DNA.Semantic proximity Read

Ultrasensitive plasma-based monitoring of tumor burden using machine-learning-guided signal enrichment.Semantic proximity Read