Article

Adoptive NK cell transfer confers neuroprotection by attenuating neuroinflammation and alpha-synuclein pathology in a mouse model of synucleionpathy

2025-08-14

Abstract excerpt

<title>Abstract</title> Background Natural killer (NK) cells are key effector lymphoid cells involved in both innate and adaptive immunity and are capable of clearing abnormally aggregated α-synuclein (aSyn). In preclinical Parkinson’s disease (PD) models, NK cell depletion worsens motor deficits and increases insoluble aSyn accumulation, suggesting a neuroprotective role. However, the therapeutic potential...

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Literature Corpus work: 58e4990a-2e67-5f62-a317-9e88e2f0550f
DOI: 10.21203/rs.3.rs-6558212/v1

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