Article
Circulating natural killer cells are phenotypically and functionally altered in age-related macular degeneration.
Cell reports. Medicine - 16 Jun 2026
Brennan Kiva, Ozaki Ema, Noone Eleanor, Palko Sarah, Byrne Kieran P, Roche Fiona, McElheron Matt, Byrne Kieva, Gibbons Luke, Robb Katie, Aktas Said, Connolly Emma, Hudson Natalie, O'Riordan Matthew M, O'Boyle Dara, Dalton Rachel, Zoller Aline, Fahey Erin, Hokamp Karsten, Feenstra Derrick, Bourke Nollaig, Campbell Matthew, Finlay David, Mulfaul Kelly, Mullins Robert F, Kenny Rose Anne, Cahill Mark T, Doyle Sarah L
Abstract excerpt
Age-related macular degeneration (AMD) is the leading cause of irreversible central blindness and can result in pathological neovascularization. Using a "human-first" approach, we identify immunotherapy as a disease modifier in models of neovascular AMD (nAMD). Plasma cytokine analysis in a large population cohort reveals an imbalance of lymphocytic cytokines associated with severity of AMD, leading to discovery...
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