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Article

Direct non-productive HIV-1 infection in a T-cell line is driven by cellular activation state and NFκB

7 Feb 2014

Abstract excerpt

BACKGROUND: Molecular latency allows HIV-1 to persist in resting memory CD4+ T-cells as transcriptionally silent provirus integrated into host chromosomal DNA. Multiple transcriptional regulatory mechanisms for HIV-1 latency have been described in the context of progressive epigenetic silencing and maintenance. However, our understanding of the determinants critical for the establishment of latency in newly...

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PMID: 24502247
DOI: 10.1186/1742-4690-11-17

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