Article

Catalytic antibodies in arrhythmogenic cardiomyopathy patients cleave desmoglein 2 and N-cadherin and impair cardiomyocyte cohesion

2023-02-08

Abstract excerpt

<h4>Aims</h4> Arrhythmogenic cardiomyopathy (AC) is a severe heart disease predisposing to ventricular arrhythmias and sudden cardiac death caused by mutations affecting intercalated disc (ICD) proteins and aggravated by physical exercise. Recently, autoantibodies targeting ICD proteins, including the desmosomal cadherin desmoglein 2 (DSG2), were reported in AC patients and were considered relevant for disease de...

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Literature Corpus work: 58bfc45c-d38e-57ca-a610-5a7a6734501d
DOI: 10.1101/2023.02.08.527624

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