Article

Autoantibodies in patients with arrhythmogenic cardiomyopathy activate GSK-3β resulting in a loss of cardiomyocyte cohesion

2025-06-27

Abstract excerpt

Arrhythmogenic cardiomyopathy (ACM) is an inherited cardiac desmosome disease, as more than 50% of affected patients carry pathogenic variants in desmosome protein-coding genes., In this study, we focused on the role and mechanisms of pathogenic and non-pathogenic autoantibodies against intercalated disc (ICD) proteins such as desmoglein2 (DSG2) in ACM patients, healthy relatives and murine ACM models. IgG fractio...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 14774696-b558-508e-b33e-3066ee8ab6a7
DOI: 10.1101/2025.06.25.661311

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Autoantibodies in patients with arrhythmogenic cardiomyopathy activate GSK-3β resulting in a loss of cardiomyocyte cohesionDOI 10.1101/2025.06.25.661311Read

Catalytic antibodies in arrhythmogenic cardiomyopathy patients cleave desmoglein 2 and N-cadherin and impair cardiomyocyte cohesionSemantic proximity Read

Molecular insight into arrhythmogenic cardiomyopathy caused by DSG2 mutations.Semantic proximity Read

Apremilast improves cardiomyocyte cohesion and arrhythmia in different models for arrhythmogenic cardiomyopathySemantic proximity Read

Comprehensive analysis of desmosomal protein remodelling identifies desmocollin-2 as potential biomarker for arrhythmogenic cardiomyopathySemantic proximity Read

Hot phase episodes in arrhythmogenic cardiomyopathy: More than just a desmoplakin issue?Semantic proximity Read

Desmoglein 2–Dependent Arrhythmogenic Cardiomyopathy Is Caused by a Loss of Adhesive FunctionSemantic proximity Read

Inflammation and Immune Response in Arrhythmogenic Cardiomyopathy: State-of-the-Art Review.Semantic proximity Read

Ser194Leu DSG2 mutation, associated with arrhythmogenic left ventricular cardiomyopathy and ventricular tachycardia.Semantic proximity Read

From Inflammation to Inheritance: Rethinking Myocarditis as the First Signal of Desmosomal CardiomyopathySemantic proximity Read

An autoantibody identifies arrhythmogenic right ventricular cardiomyopathy and participates in its pathogenesisSemantic proximity Read

Desmosomal protein degradation as an underlying cause of arrhythmogenic cardiomyopathy.Semantic proximity Read

Mechanistic insights into arrhythmogenic right ventricular cardiomyopathy caused by desmocollin-2 mutationsSemantic proximity Read