Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Desmoglein 2–Dependent Arrhythmogenic Cardiomyopathy Is Caused by a Loss of Adhesive Function

18 Jun 2015

Abstract excerpt

BACKGROUND: The desmosomal cadherin desmoglein 2 (Dsg2) localizes to the intercalated disc coupling adjacent cardiomyocytes. Desmoglein 2 gene (DSG2) mutations cause arrhythmogenic cardiomyopathy (AC) in human and transgenic mice. AC is characterized by arrhythmia, cardiodilation, cardiomyocyte necrosis with replacement fibrosis, interstitial fibrosis, and intercalated disc dissociation. The genetic DSG2...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cardiac Arrhythmias and Treatments
Share to Cardiac electrophysiology and arrhythmias
Share to Cardiovascular Effects of Exercise

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 26085008
DOI: 10.1161/circgenetics.114.000974

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Desmoglein 2–Dependent Arrhythmogenic Cardiomyopathy Is Caused by a Loss of Adhesive FunctionPMID 26085008Read ↗

Transgenic mice overexpressing desmocollin-2 (DSC2) develop cardiomyopathy associated with myocardial inflammation and fibrotic remodelingSemantic proximity Read ↗

Defective Desmosomal Adhesion Causes Arrhythmogenic Cardiomyopathy by Involving an Integrin-αVβ6/TGF-β Signaling CascadeSemantic proximity Read ↗

Desmoglein 2 mutant mice develop cardiac fibrosis and dilation.Semantic proximity Read ↗

Defective Desmosomal Adhesion Causes Arrhythmogenic Cardiomyopathy by involving an Integrin-αVβ6/TGF-β Signaling CascadeSemantic proximity Read ↗

Molecular insight into arrhythmogenic cardiomyopathy caused by DSG2 mutations.Semantic proximity Read ↗

A missense variant in desmoglein-2 predisposes to dilated cardiomyopathy.Semantic proximity Read ↗

Ser194Leu DSG2 mutation, associated with arrhythmogenic left ventricular cardiomyopathy and ventricular tachycardia.Semantic proximity Read ↗

Early cardiac inflammation as a driver of murine model of Arrhythmogenic CardiomyopathySemantic proximity Read ↗

Altered Electrical, Biomolecular, and Immunologic Phenotypes in a Novel Patient-Derived Stem Cell Model of Desmoglein-2 Mutant ARVCSemantic proximity Read ↗

Knockout of SORBS2 Protein Disrupts the Structural Integrity of Intercalated Disc and Manifests Features of Arrhythmogenic Cardiomyopathy.Semantic proximity Read ↗

Comprehensive analysis of desmosomal protein remodelling identifies desmocollin-2 as potential biomarker for arrhythmogenic cardiomyopathySemantic proximity Read ↗

The C-terminal unique region of desmoglein 2 inhibits its internalization via tail-tail interactions.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.