Article

Apremilast improves cardiomyocyte cohesion and arrhythmia in different models for arrhythmogenic cardiomyopathy

2025-04-23

Abstract excerpt

<h4>Background</h4> Arrhythmogenic cardiomyopathy (ACM) is a genetically inherited desmosome heart disease leading to life-threatening arrhythmias and sudden cardiac death. Currently, ACM treatment paradigms are merely symptom targeting. Recently, apremilast was shown to stabilize keratinocyte adhesion in the desmosomal disease pemphigus vulgaris. Therefore, this study investigated whether apremilast can be a the...

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Literature Corpus work: b45521eb-934b-5153-a462-bc6ec226c0cf
DOI: 10.1101/2025.04.17.649297

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