Article

Defective Desmosomal Adhesion Causes Arrhythmogenic Cardiomyopathy by involving an Integrin-αVβ6/TGF-β Signaling Cascade

2021-09-03

Abstract excerpt

<h4>Background</h4> Arrhythmogenic Cardiomyopathy (ACM) is characterized by progressive loss of cardiomyocytes with fibrofatty replacement, systolic dysfunction and life-threatening arrhythmias. A substantial proportion of ACM is caused by mutations in genes of the desmosomal cell-cell adhesion complex, but the underlying mechanisms are not well understood. So far, treatment options are only symptomatic. Here, we...

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Literature Corpus work: c58fe4c2-5b2f-575c-9863-15ba58a1e98d
DOI: 10.1101/2021.09.02.458734

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