Article

Single-cell analysis reveals diverse stromal subsets associated with immune evasion in triple-negative breast cancer

2020-06-06

Abstract excerpt

The tumour stroma regulates nearly all stages of carcinogenesis. Stromal heterogeneity in human triple-negative breast cancers (TNBCs) remains poorly understood, limiting the development of stromal-targeted therapies. Single cell RNA-sequencing of five TNBCs revealed two cancer-associated fibroblast (CAF) and two perivascular-like (PVL) subpopulations. CAFs clustered into two states, the first with features of myo...

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Literature Corpus work: 7843650d-1089-558a-a61f-9ced27350527
DOI: 10.1101/2020.06.04.135327

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