Article

Pre-neoplastic stromal cells drive BRCA1-mediated breast tumorigenesis

2021-10-21

Abstract excerpt

<h4>Summary</h4> Women with germline mutations in BRCA1 (BRCA1 +/mut ) have increased risk for developing hereditary breast cancer 1, 2 . Cancer initiation in BRCA1 +/mut is associated with pre-malignant changes in the breast epithelium including altered differentiation 3–5 , proliferative stress 6 and genomic instability 7 . However, the role of the epithelium- associated stromal niche during BRCA1-driven...

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Literature Corpus work: 2b1534d1-dd52-5a39-8c4a-126d8f56be26
DOI: 10.1101/2021.10.20.465221

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