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Article

Tumour cell-derived Wnt7a recruits and activates fibroblasts to promote tumour aggressiveness

18 Jan 2016

Abstract excerpt

Stromal fibroblast recruitment to tumours and activation to a cancer-associated fibroblast (CAF) phenotype has been implicated in promoting primary tumour growth and progression to metastatic disease. However, the mechanisms underlying the tumour:fibroblast crosstalk that drive the intertumoural stromal heterogeneity remain poorly understood. Using in vivo models we identify Wnt7a as a key factor secreted...

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PMID: 26777421
DOI: 10.1038/ncomms10305

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