Article
The proliferative activity levels of each immune cell population evaluated by mass cytometry are linked to the clinical phenotypes of systemic lupus erythematosus.
International immunology - 21 Jan 2023
Kajihara Akiko, Morita Takayoshi, Kato Yasuhiro, Konaka Hachiro, Murakami Teruaki, Yamaguchi Yuta, Koyama Shohei, Takamatsu Hyota, Nishide Masayuki, Maeda Yuichi, Watanabe Akane, Nishida Sumiyuki, Hirano Toru, Shima Yoshihito, Narazaki Masashi, Kumanogoh Atsushi
Abstract excerpt
Systemic lupus erythematosus (SLE) is a heterogeneous autoimmune disease, and many peripheral immune cell populations (ICPs) are thought to be altered according to the course of the disease. However, it is unclear which ICPs are associated with the clinical phenotypes of SLE. We analyzed peripheral blood mononuclear cells (PBMCs) of 28 SLE patients using mass cytometry and identified 30 ICPs. We determined the...
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