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Transcriptomic imputation of genetic risk variants uncovers novel whole-blood biomarkers of Parkinson’s disease

8 May 2024

Abstract excerpt

Blood-based gene expression signatures could potentially be used as biomarkers for PD. However, it is unclear whether genetically-regulated transcriptomic signatures can provide novel gene candidates for use as PD biomarkers. We leveraged on the Genotype-Tissue Expression (GTEx) database to impute whole-blood transcriptomic expression using summary statistics of three large-scale PD GWAS. A random forest...

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PMID: 38719867
DOI: 10.1038/s41531-024-00698-y

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