Article

The Quest for a Universal Parkinson’s Transcriptomics Signature is Derailed by Inherent Variability between Patients

2025-08-25

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Objective</h4> To systematically evaluate the reproducibility and clinical utility of published blood mRNA-based gene signatures for classifying PD from healthy controls, and to uncover the pitfalls that limit their performances. <h4>Methods</h4> We validated the classification performance of 13 gene signatures unique for PD (published 2015-2025) using the Parkinson’s Progression Markers I...

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Literature Corpus work: 6579009f-fc39-5a9d-a5c0-9b5de272eda3
DOI: 10.1101/2025.08.20.671280

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