Article

Genome-Wide Uncertainty-Moderated Extraction of Signal Annotations from Multi-Sample Functional Genomics Data

2025-02-08

Abstract excerpt

We present Consenrich, a simple but principled technique for genome-wide estimation of signals hidden in noisy multi-sample sequencing-based functional genomics datasets. Consenrich appeals to a sequential prediction-correction framework and models both the spatial dependencies between proximal loci and regional, sample-specific noise processes that corrupt sequencing data. Experiments reveal distinct improvement...

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Literature Corpus work: 586a39c0-693a-5f04-8dd6-c8345579c57e
DOI: 10.1101/2025.02.05.636702

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