Quantitative omnigenic model discovers interpretable genome-wide associations.

Abstract excerpt

As their statistical power grows, genome-wide association studies (GWAS) have identified an increasing number of loci underlying quantitative traits of interest. These loci are scattered throughout the genome and are individually responsible only for small fractions of the total heritable trait variance. The recently proposed omnigenic model provides a conceptual framework to explain these observations by...

Topics

• Genome-Wide Association Study
• Quantitative Trait Loci
• Models, Genetic
• Gene Regulatory Networks
• Saccharomyces cerevisiae
• Polymorphism, Single Nucleotide