Article

gRely: Relyability for genome trained sequence-to-expression models

2026-05-27

Abstract excerpt

Sequence-to-function (S2F) models predict molecular phenotypes from DNA sequence and are increasingly applied to variant effect prediction (VEP), where the goal is to quantify how genetic variants alter gene expression. However, S2F model predictions are not uniformly reliable: accuracy varies substantially across variants, genes, and tissues, and current practice relies on crude magnitude thresholding to enrich f...

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Literature Corpus work: 3fc8ef9b-b4c3-55ad-aaeb-67474c7b03ab
DOI: 10.64898/2026.05.23.727431

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