Article

SuSiNE: Genetic fine-mapping with signed functional priors and multi-basin ensembling

2026-08-06

Abstract excerpt

Genetic fine-mapping identifies causal variants within trait-associated loci, but linkage disequilibrium (LD), and wide datasets complicate this sparse variable-selection problem. SuSiE is popular for its fast variational inference, posterior inclusion probabilities (PIPs), and credible sets, yet a single fit can fail to resolve LD ambiguity, converge to a poor local optimum, or misrepresent uncertainty over compe...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: f4574fd5-d9a9-5753-9abb-0c9edb579389
DOI: 10.64898/2026.07.31.742084

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

SuSiNE: Genetic fine-mapping with signed functional priors and multi-basin ensemblingDOI 10.64898/2026.07.31.742084Read

SparsePro: an efficient fine-mapping method integrating summary statistics and functional annotationsSemantic proximity Read

SparsePro: An efficient fine-mapping method integrating summary statistics and functional annotations.Semantic proximity Read

gRely: Relyability for genome trained sequence-to-expression modelsSemantic proximity Read

Improving fine-mapping by modeling infinitesimal effectsSemantic proximity Read

Relational biological structure improves fine-mapping of causal GWAS variants under weak signalSemantic proximity Read

MESuSiE enables scalable and powerful multi-ancestry fine-mapping of causal variants in genome-wide association studies.Semantic proximity Read

A consensus variant-to-function score to functionally prioritize variants for diseaseSemantic proximity Read

Improving fine-mapping by modeling infinitesimal effects.Semantic proximity Read

MultiSuSiE improves multi-ancestry fine-mapping in All of Us whole-genome sequencing data.Semantic proximity Read

BEATRICE: Bayesian Fine-mapping from Summary Data using Deep Variational InferenceSemantic proximity Read

Fast and flexible joint fine-mapping of multiple traits via the Sum of Single Effects model.Semantic proximity Read

Path-Probability Models Outperform Point-Estimate Scores for Noncoding GWAS Gene PrioritizationSemantic proximity Read