Article
MT-HESS: an efficient Bayesian approach for simultaneous association detection in OMICS datasets, with application to eQTL mapping in multiple tissues.
Bioinformatics (Oxford, England) - 15 Feb 2016
Lewin Alex, Saadi Habib, Peters James E, Moreno-Moral Aida, Lee James C, Smith Kenneth G C, Petretto Enrico, Bottolo Leonardo, Richardson Sylvia
Abstract excerpt
MOTIVATION: Analysing the joint association between a large set of responses and predictors is a fundamental statistical task in integrative genomics, exemplified by numerous expression Quantitative Trait Loci (eQTL) studies. Of particular interest are the so-called ': hotspots ': , important genetic variants that regulate the expression of many genes. Recently, attention has focussed on whether eQTLs are common...
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