Article

CRISPR/Cas9 screen reveals a role of purine synthesis for estrogen receptor α activity and tamoxifen resistance of breast cancer cells

2022-06-03

Abstract excerpt

In breast cancer, resistance to endocrine therapies that target estrogen receptor α (ERα), such as tamoxifen and fulvestrant, remains a major clinical problem. Whether and how ERα+ breast cancers switch from being estrogen-dependent to -independent remains unclear. With a genome-wide CRISPR/Cas9 knockout screen, we identified new biomarkers and potential therapeutic targets of endocrine resistance. We demonstrate...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 5852a2fb-dca3-5b8b-9b94-fce8057779ae
DOI: 10.1101/2022.06.03.494664

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

CRISPR/Cas9 screen reveals a role of purine synthesis for estrogen receptor α activity and tamoxifen resistance of breast cancer cellsDOI 10.1101/2022.06.03.494664Read

Antiestrogen Resistant Cell Lines Expressing Estrogen Receptor α Mutations Upregulate the Unfolded Protein Response and are Killed by BHPI.Semantic proximity Read

Resistance to endocrine therapy in breast cancer: molecular mechanisms and future goalsSemantic proximity Read

CRISPRa screen identifies a role for c-KIT signaling in tamoxifen resistance, potentially through upregulation of ABC transportersSemantic proximity Read

Allele-specific gene regulation, phenotypes, and therapeutic vulnerabilities in estrogen receptor alpha mutant endometrial cancerSemantic proximity Read

Allele-Specific Gene Regulation, Phenotypes, and Therapeutic Vulnerabilities in Estrogen Receptor Alpha-Mutant Endometrial Cancer.Semantic proximity Read

Mutation site and context dependent effects of ESR1 mutation in genome-edited breast cancer cell models.Semantic proximity Read

Advances in breast cancer research using CRISPR/Cas9 systemSemantic proximity Read

Understanding the mechanisms of action of estrogen receptor mutations in metastatic breast cancerSemantic proximity Read

miR-489 Confines Uncontrolled Estrogen Signaling Through a Negative Feedback Mechanism and Regulates Tamoxifen Resistance in Breast CancerSemantic proximity Read

Endocrine resistance in breast cancer--An overview and update.Semantic proximity Read

Genome engineering for estrogen receptor mutations reveals differential responses to anti-estrogens and new prognostic gene signatures for breast cancer.Semantic proximity Read

Applications of CRISPR Technology to Breast Cancer and Triple Negative Breast Cancer ResearchSemantic proximity Read