Article

CRISPRa screen identifies a role for c-KIT signaling in tamoxifen resistance, potentially through upregulation of ABC transporters

2022-08-22

Abstract excerpt

Resistance to endocrine therapy is a common problem in patients with estrogen receptor alpha (ER α ) positive breast cancer. In this study, we took a non-biased genome-wide approach to identify novel mechanisms of endocrine resistance using a clustered regularly interspaced short palindromic repeats (CRISPR) activating (CRISPRa) screen. Results from the screen identified 109 candidate resistance-associated genes,...

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Literature Corpus work: 524f7f92-41a0-5d5d-9cd3-f63cca2f9344
DOI: 10.1101/2022.08.22.504845

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