Article

Understanding the mechanisms of action of estrogen receptor mutations in metastatic breast cancer

2019-01-01

Abstract excerpt

Estrogen receptor (ER) is a key driver of breast cancer development and progression and is the target for endocrine therapies. Use of endocrine agents has contributed greatly to reductions in breast cancer mortality over the last three decades. However, many patients develop resistance to these therapies, for reasons that remain unclear. Recent studies have identified ESR1 (ER) mutations in metastatic breast cance...

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Literature Corpus work: 0819e0d2-dddb-56e6-838f-6252261ac201
DOI: 10.25560/87273

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