Article
Induced Pluripotent Stem Cells From Subjects With Primary Sclerosing Cholangitis Develop a Senescence Phenotype Following Biliary Differentiation.
Hepatology communications - 1 Feb 2022
Jalan-Sakrikar Nidhi, De Assuncao Thiago M, Navarro-Corcuera Amaia, Hamdan Feda H, Loarca Lorena, Kirkeby Lindsey A, Resch Zachary T, O'Hara Steven P, Juran Brian D, Lazaridis Konstantinos N, Rosen Charles B, Heimbach Julie K, Taner Timucin, Shah Vijay H, LaRusso Nicholas F, Huebert Robert C
Abstract excerpt
Primary sclerosing cholangitis (PSC) is a chronic fibroinflammatory disease of the biliary tract characterized by cellular senescence and periportal fibrogenesis. Specific disease features that are cell intrinsic and either genetically or epigenetically mediated remain unclear due in part to a lack of appropriate, patient-specific, in vitro models. Recently, our group developed systems to create induced...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.