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Liver transcriptome analysis reveals PSC-attributed gene set associated with fibrosis progression

12 Nov 2024

Abstract excerpt

Background & Aims Primary sclerosing cholangitis (PSC) is a chronic heterogenous cholangiopathy with unknown etiology where chronic inflammation of the bile ducts leads to multifocal biliary strictures and biliary fibrosis with consecutive cirrhosis development. We here aimed to identify a PSC-specific gene signature associated with biliary fibrosis development. Methods We performed RNA-sequencing of 47 liver...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 39996122
DOI: 10.1016/j.jhepr.2024.101267

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