Article

Genetic inactivation of the USP19 deubiquitinase regulates a-synuclein ubiquitination and inhibits accumulation of Lewy body like aggregates in mice

2022-12-22

Abstract excerpt

<h4>ABSTRACT</h4> The USP19 deubiquitinase is found in a locus associated with Parkinson’s Disease (PD), interacts with heat shock proteins and promotes secretion of a-synuclein (a-syn) through the misfolding associated protein secretion (MAPS) pathway. Since these processes might modulate the processing of a-syn aggregates during the progression of PD, we tested the effect of USP19 knockout (KO) in mice expressi...

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Literature Corpus work: 5844251d-b5f9-5de0-8c1d-66ace53bcda3
DOI: 10.1101/2022.12.21.521125

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Genetic inactivation of the USP19 deubiquitinase regulates a-synuclein ubiquitination and inhibits accumulation of Lewy body like aggregates in miceDOI 10.1101/2022.12.21.521125Read

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