Article

An optimized derivative of an endogenous CXCR4 antagonist prevents atopic dermatitis and airway inflammation

2020-08-29

Abstract excerpt

<h4>Background</h4> Aberrant CXCR4/CXCL12 signaling is involved in many pathophysiological processes including chronic inflammatory diseases. Thus, the chemokine receptor CXCR4 is a promising target for the therapy of inflammatory disorders, such as atopic dermatitis or allergic asthma. A natural fragment of serum albumin, named EPI-X4, has previous been identified as endogenous peptide antagonist and inverse ago...

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Literature Corpus work: 5843a50d-cfd5-5e07-a454-9a2ffd070622
DOI: 10.1101/2020.08.28.272781

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