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Article

At the Bench: Pre-clinical evidence for multiple functions of CXCR4 in cancer.

Journal of leukocyte biology - 1 May 2021

Luker Gary D, Yang Jinming, Richmond Ann, Scala Stefania, Festuccia Claudio, Schottelius Margret, Wester Hans-Jürgen, Zimmermann Johann

Abstract excerpt

Signaling through chemokine receptor, C-X-C chemokine receptor type 4 (CXCR4) regulates essential processes in normal physiology, including embryogenesis, tissue repair, angiogenesis, and trafficking of immune cells. Tumors co-opt many of these fundamental processes to directly stimulate proliferation, invasion, and metastasis of cancer cells. CXCR4 signaling contributes to critical functions of stromal cells in...

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Identifiers

PMID: 33104270
DOI: 10.1002/JLB.2BT1018-715RR
PMCID: PMC8254203

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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