Article

Biomolecular models of EPI-X4 binding to CXCR4 allow the rational optimization of peptides with therapeutic potential

2020-10-24

Abstract excerpt

<h4>ABSTRACT</h4> The Endogenous Peptide Inhibitor of CXCR4 (EPI-X4) is a body-own fragment of albumin and specific antagonist of the CXC-motif-chemokine receptor 4 (CXCR4). CXCR4 signaling is induced by its sole chemokine ligand CXCL12 and is involved in a plethora of functions including cell homing, differentiation, survival and angiogenesis. Consequently, dysregulation of CXCR4 is involved in a variety of diso...

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Literature Corpus work: 3154d763-8eba-5b08-8aff-ea68c3888c5d
DOI: 10.1101/2020.10.23.352708

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