Article

Self-reactive B cells traverse a perfect storm of somatic mutagenesis to cause a virus-induced autoimmune disease

2024-01-08

Abstract excerpt

<h4>Summary</h4> The unexplained association between infection and autoimmune disease is strongest for hepatitis C virus-induced cryoglobulinemic vasculitis (HCV-CV). We traced the evolution of the pathogenic rheumatoid factor (RhF) autoantibodies in four HCV-CV patients by deep single cell multi-omic analysis, revealing three sources of B cell somatic mutation converged to drive accumulation of a large disease c...

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Literature Corpus work: 5838d6fa-09a3-5411-8a50-61ae7d4e85d9
DOI: 10.1101/2024.01.07.574561

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