Article
Clonal evolution and antigen recognition of anti-nuclear antibodies in acute systemic lupus erythematosus.
Scientific reports - 27 Nov 2017
Sakakibara Shuhei, Arimori Takao, Yamashita Kazuo, Jinzai Hideyuki, Motooka Daisuke, Nakamura Shota, Li Songling, Takeda Kazuya, Katayama Jun, El Hussien Marwa Ali, Narazaki Masashi, Tanaka Toshio, Standley Daron M, Takagi Junichi, Kikutani Hitoshi
Abstract excerpt
The evolutional process of disease-associated autoantibodies in systemic lupus erythematosus (SLE) remains to be established. Here we show intraclonal diversification and affinity maturation of anti-nuclear antibody (ANA)-producing B cells in SLE. We identified a panel of monoclonal ANAs recognizing nuclear antigens, such as double-stranded DNA (dsDNA) and ribonucleoproteins (RNPs) from acute SLE subjects. These...
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