A triad of somatic mutagenesis converges in self-reactive B cells to cause a virus-induced autoimmune disease.

doi:10.1016/j.immuni.2024.12.011

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Article

A triad of somatic mutagenesis converges in self-reactive B cells to cause a virus-induced autoimmune disease.

Immunity - 11 Feb 2025

Young Clara, Singh Mandeep, Jackson Katherine J L, Field Matt A, Peters Timothy J, Angioletti-Uberti Stefano, Frenkel Daan, Ravishankar Shyamsundar, Gupta Money, Wang Jing J, Agapiou David, Faulks Megan L, Al-Eryani Ghamdan, Luciani Fabio, Gordon Tom P, Reed Joanne H, Danta Mark, Carr Andrew, Kelleher Anthony D, Dore Gregory J, Matthews Gail, Brink Robert, Bull Rowena A, Suan Dan, Goodnow Christopher C

Abstract excerpt

The unexplained association between infection and autoimmune disease is strongest for hepatitis C virus-induced cryoglobulinemic vasculitis (HCV-cryovas). To analyze its origins, we traced the evolution of pathogenic rheumatoid factor (RF) autoantibodies in four HCV-cryovas patients by deep single-cell multi-omic analysis, revealing three sources of B cell somatic mutation converged to drive the accumulation of a...

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PMID: 39818208
DOI: 10.1016/j.immuni.2024.12.011

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