Article

HLA-B*39:06 Efficiently Mediates Type 1 Diabetes in a Mouse Model Incorporating Reduced Thymic Insulin Expression <sup>1</sup>

2018-02-13

Abstract excerpt

<h4>ABSTRACT</h4> Type 1 diabetes (T1D) is characterized by T cell-mediated destruction of the insulin-producing βcells of the pancreatic islets. Among the loci associated with T1D risk, those most predisposing are found in the MHC region. HLA-B*39:06 is the most predisposing class I MHC allele and is associated with an early age of onset. To establish an NOD mouse model for the study of HLA-B*39:06, we expressed...

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Literature Corpus work: 5834511b-928f-5086-9a02-a7edf2b6209d
DOI: 10.1101/264531

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