Multi-omics analysis identifies RFX7 targets involved in tumor suppression and neuronal processes

Abstract excerpt

Recurrently mutated in lymphoid neoplasms, the transcription factor RFX7 is emerging as a tumor suppressor. Previous reports suggested that RFX7 may also have a role in neurological and metabolic disorders. We recently reported that RFX7 responds to p53 signaling and cellular stress. Furthermore, we found RFX7 target genes to be dysregulated in numerous cancer types also beyond the hematological system. However, o...

Topics

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• Disease Models, Animal
• DNA Copy Number Variations
• Down-Regulation
• Gene Expression Regulation, Neoplastic
• Genome-Wide Association Study
• Leukemia, Lymphoid
• Lymphoma
• Regulatory Factor X Transcription Factors

Identifiers and source

Literature Corpus work

f80ab45f-88b4-5c10-837d-03856b8e9bd4

DOI

10.1101/2022.12.05.519097