Article

Vitamin K-dependent carboxylation in osteoblasts regulates bone resorption through GAS6 in male mice

2025-09-09

Abstract excerpt

Studies in humans suggest that vitamin K is involved in the regulation of bone remodeling, but the precise mechanism at play remains unknown. In cells, vitamin K functions as a co-factor for the γ-glutamyl carboxylase (GGCX), an enzyme responsible for the conversion of glutamic acid residues (Glu) into γ-carboxyglutamic acid (Gla) residues in secreted proteins. We aim here at determining the role of γ-carboxylatio...

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Literature Corpus work: 582db5d8-31ff-5060-afd5-2a8457b4597b
DOI: 10.1101/2025.09.08.673085

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