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Article

Impaired skeletal development in interleukin-6-transgenic mice: a model for the impact of chronic inflammation on the growing skeletal system.

Arthritis and rheumatism - 1 Nov 2006

De Benedetti Fabrizio, Rucci Nadia, Del Fattore Andrea, Peruzzi Barbara, Paro Rita, Longo Maurizio, Vivarelli Marina, Muratori Flaminia, Berni Silvia, Ballanti Paola, Ferrari Serge, Teti Anna

Abstract excerpt

OBJECTIVE: To identify the mediator responsible for the impact of chronic inflammation on skeletal development in children (bone loss, defective peak bone mass accrual, stunted growth), we evaluated the effects of chronic interleukin-6 (IL-6) overexpression on the skeletons of growing prepubertal mice. METHODS: We studied IL-6-transgenic mice that had high circulating IL-6 levels since birth. Trabecular and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 17075861
DOI: 10.1002/art.22175

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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