Article
Systemic Jak1 activation causes extrarenal calcitriol production and skeletal alterations provoking stunted growth.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Jul 2021
Fuente Rocío, Gehring Nicole, Bettoni Carla, Gil-Peña Helena, Alonso-Durán Laura, Michalke Bernhard, Santos Fernando, Wagner Carsten A, Rubio-Aliaga Isabel
Abstract excerpt
Mineral homeostasis is regulated by a complex network involving endocrine actions by calcitriol, parathyroid hormone (PTH), and FGF23 on several organs including kidney, intestine, and bone. Alterations of mineral homeostasis are found in chronic kidney disease and other systemic disorders. The interplay between the immune system and the skeletal system is not fully understood, but cytokines play a major role in...
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