Article

Dysfunctional mechanotransduction regulates the progression of PIK3CA-driven vascular malformations

2024-08-23

Abstract excerpt

Somatic activating mutations in PIK3CA are common drivers of vascular and lymphatic malformations. Despite common biophysical signatures of tissues susceptible to lesion formation, including compliant extracellular matrix and low rates of perfusion, lesions vary in clinical presentation from localized cystic dilatation to diffuse and infiltrative vascular dysplasia. The mechanisms driving the differences in disea...

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Identifiers and source

Literature Corpus work: 5825aba3-fe37-5be5-973b-0da1b4851b2c
DOI: 10.1101/2024.08.22.609165

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