Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Constitutively active PIK3CA mutations are expressed by lymphatic and vascular endothelial cells in capillary lymphatic venous malformation.

Angiogenesis - 1 Aug 2020

Le Cras Timothy D, Goines Jillian, Lakes Nora, Pastura Patricia, Hammill Adrienne M, Adams Denise M, Boscolo Elisa

Abstract excerpt

Capillary lymphatic venous malformations (CLVM) are complex vascular anomalies characterized by aberrant and enlarged lymphatic and blood vessels. CLVM appear during fetal development and enlarge after birth, causing life-long complications such as coagulopathy, pulmonary embolism, chronic pain, and disfigurement. Treatment includes surgical debulking, amputation, and recurrent sclerotherapy. Somatic, mosaic...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Capillaries
Share to Child, Preschool

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Class I Phosphatidylinositol 3-Kinases

Share to Human Umbilical Vein Endothelial Cells

Share to Infant

Share to Lymphatic Vessels

Share to Mice, Nude

Share to Vascular Malformations

Source

Open in PubMed Open full text

Identifiers

PMID: 32350708
DOI: 10.1007/s10456-020-09722-0
PMCID: PMC7311380

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Constitutively active PIK3CA mutations are expressed by lymphatic and vascular endothelial cells in capillary lymphatic venous malformation.PMID 32350708Read ↗

AKT hyper-phosphorylation associated with PI3K mutations in lymphatic endothelial cells from a patient with lymphatic malformation.Semantic proximity Read ↗

Activating PIK3CA alleles and lymphangiogenic phenotype of lymphatic endothelial cells isolated from lymphatic malformations.Semantic proximity Read ↗

Immunoregulatory subtype of dermal lymphatic endothelial cells at capillary terminals drives lymphatic malformationsSemantic proximity Read ↗

PIK3CA mutations are specifically localized to lymphatic endothelial cells of lymphatic malformations.Semantic proximity Read ↗

Somatic Activating PIK3CA Mutations Cause Venous Malformation.Semantic proximity Read ↗

Blockade of VEGF-C signaling inhibits lymphatic malformations driven by oncogenic PIK3CA mutation.Semantic proximity Read ↗

Somatic PIK3CA mutations as a driver of sporadic venous malformations.Semantic proximity Read ↗

Somatic activating <i>BRAF</i> variants cause isolated lymphatic malformationsSemantic proximity Read ↗

Somatic activating mutations in Pik3ca cause sporadic venous malformations in mice and humans.Semantic proximity Read ↗

A somatic mutation in PIK3CD unravels a novel candidate gene for lymphatic malformation.Semantic proximity Read ↗

Somatic Loss-of-Function PIK3R1 and Activating Non-hotspot PIK3CA Mutations Associated with Capillary Malformation with Dilated Veins (CMDV)Semantic proximity Read ↗

Somatic activating BRAF variants cause isolated lymphatic malformationsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.