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Article

PI3K/AKT/mTOR axis in vascular malformations: from molecular insights to targeted clinical trials.

Orphanet journal of rare diseases - 22 Dec 2025

Zheng Yuan-Yang, Hua Chen, Lin Xiao-Xi

Abstract excerpt

BACKGROUND: Vascular malformations are congenital disorders characterized by abnormal blood and/or lymphatic vessels, often leading to pain, functional impairment, and severe complications. Recent advances in molecular genetics have identified key mutations and signaling pathway aberrations, particularly in the PI3K/AKT/mTOR axis, as critical contributors to the etiology of vascular malformations. MAIN BODY: The...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 41430313
DOI: 10.1186/s13023-025-04115-2
PMCID: PMC12723890

Genes

PIK3CA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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