Article

Phenotypic Transition of Vascular Smooth Muscle Cells Induced by Endothelial TIE2 Mutations in Venous Malformations

2022-09-21

Abstract excerpt

Venous malformations (VMs) are congenital vascular malformations characterized by a chronically enlarged and malformed venous cavity. Although TIE2 mutation has been commonly recognized as a vital genetic landscape in VMs, the role of TIE2 in regulating the contraction function of smooth muscle cells remains unclear. We generated mouse models through endothelial germline/somatic expression of Tie2-R848W , which ha...

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Literature Corpus work: 236d00bb-42c5-5c39-ab3e-e4d164465999
DOI: 10.21203/rs.3.rs-2055243/v1

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